BIOMAT Database Logo BIOMAT Database Logo

Epoxypeptide antibiotic tetaine mimics peptides in transport to bacteria. 1981

H Chmara, and B Woynarowska, and E Borowski

Tetaine induced the lysis of Escherichia coli cells. Several di- and tripeptides were found to protect this cells against tetaine action. Certain peptides are able to diminish the inhibition by tetaine of diaminopimelic acid incorporation into peptidoglycan and the extent of this corresponds to the protection of the cells against the tetaine-induced lysis. The data indicate that tetaine enters E. coli cells predominantly by dipeptide permease and in part by one or more oligopeptide permease system. A number of di- and tripeptides diminished the inhibitory effect of tetaine on the incorporation of lysine into peptidoglycan of Staphylococcus aureus Oxford. In contrast to E. coli, tetaine seems to be transported into S. aureus by a single transport system.

UI MeSH Term Description Entries
D009842 Oligopeptides Peptides composed of between two and twelve amino acids. Oligopeptide
D004151 Dipeptides Peptides composed of two amino acid units. Dipeptide
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001419 Bacteria One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive. Eubacteria
D001433 Bacteriolysis Rupture of bacterial cells due to mechanical force, chemical action, or the lytic growth of BACTERIOPHAGES. Bacteriolyses
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic

Related Publications

H Chmara, and B Woynarowska, and E Borowski
[Works on the new antibiotic tetaine].
January 1955, Acta poloniae pharmaceutica,
H Chmara, and B Woynarowska, and E Borowski
Paper-chromatography of the antibiotic tetaine.
January 1957, Biuletyn Instytutu Medycyny Morskiej w Gdansku,
H Chmara, and B Woynarowska, and E Borowski
Active transport of peptides in bacteria.
December 1980, Biochemical Society transactions,
H Chmara, and B Woynarowska, and E Borowski
[Improved method of production of antibiotic tetaine. II. Obtaining pure antibiotic].
January 1957, Acta biochimica Polonica,
H Chmara, and B Woynarowska, and E Borowski
Antibiotic uptake and transport by bacteria.
January 1990, Scandinavian journal of infectious diseases. Supplementum,
H Chmara, and B Woynarowska, and E Borowski
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.
June 2018, Nature microbiology,
H Chmara, and B Woynarowska, and E Borowski
The inactivation of glucosamine synthetase from bacteria by anticapsin, the C-terminal epoxyamino acid of the antibiotic tetaine.
May 1984, Biochimica et biophysica acta,
H Chmara, and B Woynarowska, and E Borowski
A novel strategy to target lethal peptides against antibiotic resistant bacteria.
April 2004, Discovery medicine,
H Chmara, and B Woynarowska, and E Borowski
The inhibition of murein synthesis in Staphylococcus aureus by the antibiotic tetaine.
December 1973, Biochemical and biophysical research communications,
H Chmara, and B Woynarowska, and E Borowski
[Isolation of tetaine, an antibiotic from the strain of Bacillus pumilus].
January 1953, Biuletyn Panstwowego Instytutu Medycyny Morskiej i Tropikalnej w Gdansku. Biulleten' Gosudarstvennogo Instituta morskoi i tropicheskoi meditsiny v Gdan'ske. Bulletin of the State Institute of Marine and Tropical Medicine in Gdansk, Pola...,
Copied contents to your clipboard!