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Chemotherapy-induced alopecia observed in cancer patients can now be prevented by a simple, effective, inexpensive and well tolerated procedure: scalp hypothermia. Refrigeration is obtained by placing on the scalp two bags filled with crushed ice 15 minutes before, and removing them 15 minutes after intravenous injection of antineoplastic drugs. Only patients treated with drug combinations that are rapidly administered (into the giving-set tube or by i.v. infusion lasting less than 60 minutes) seem to benefit from scalp hypothermia. The fact that good results were obtained with those drugs (adriamycin, cyclophosphamide, 5-fluorouracil, methotrexate, vincristine) and modes of administration that are most commonly used in women with breast cancer or ovarian cancer makes this procedure extremely interesting.
D Belpomme, and
L Mignot, and
M Grandjean, and
E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
January 1985,
Acta radiologica. Oncology,
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E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
August 2017,
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D Belpomme, and
L Mignot, and
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E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
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February 2006,
Annals of oncology : official journal of the European Society for Medical Oncology,
D Belpomme, and
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M Grandjean, and
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A Le Rol, and
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September 1981,
Orvosi hetilap,
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L Mignot, and
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M Marty, and
M Boiron
May 1978,
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D Belpomme, and
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M Grandjean, and
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A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
December 1990,
The Netherlands journal of medicine,
D Belpomme, and
L Mignot, and
M Grandjean, and
E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
May 1987,
Journal of advanced nursing,
D Belpomme, and
L Mignot, and
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E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
November 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
D Belpomme, and
L Mignot, and
M Grandjean, and
E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
February 1981,
British medical journal (Clinical research ed.),
D Belpomme, and
L Mignot, and
M Grandjean, and
E Pujade-Lauraine, and
A Le Rol, and
C Gisselbrecht, and
M Marty, and
M Boiron
February 2016,
Journal of thermal biology,
