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The distribution of T-lymphocyte subpopulations bearing receptors for the Fc portion of IgG (TG) or IgM (TM) was monitored in 22 renal allograft recipients treated with immunosuppressive therapy and in 10 uraemic patients on haemodialysis. No significant difference in the distribution of T cells and T-cell subsets was found between normal controls and haemodialysed patients. In transplanted patients, however, a significant reduction of the total T-cell percentage (P less than 0.005), of TM subset percentage (P less than 0.025) and absolute number (P less than 0.005) and of TG absolute number (P less than 0.05) was observed. Considering patients with allografts functioning for more than 1 year only, the reduction in TM cells in terms of percentage (P less than 0.0005) and absolute number (P less than 0.025) was significant, while TG subset levels did not change significantly. In patients transplanted less than 1 year previous to our study, total T cells and T-cell subsets were reduced significantly only as absolute numbers. During the 1st year we observed several increments of TM values towards normal levels, especially in the first 2 months after transplantation. During this period, TM subset levels sharply increased at acute rejection crisis and returned to previous values with rejection reversal. Our results suggest that the TM subset plays a prominent role in the mechanisms involved in the immunological response to allografts, and therefore repeated TM cell monitoring could be useful in the follow-up of renal transplant patients.
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
January 1995,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
April 1978,
Journal of immunology (Baltimore, Md. : 1950),
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
September 2002,
Transplantation proceedings,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
April 1988,
Journal of neurosurgery,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
September 1982,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
October 1981,
Journal of the neurological sciences,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
November 1987,
Harefuah,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
February 1982,
Clinical and experimental immunology,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
December 2003,
Transplantation,
G Luciani, and
N Maggiano, and
F Citterio, and
L Lauriola, and
U Pozzetto, and
M Piantelli, and
M Castagneto, and
P Musiani
May 1984,
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
