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Fully synthetic human insulin (CGP 12'831) was compared to porcine insulin in identical and non-identical formula by intravenous insulin tolerance tests in 12 volunteers. The half-lives of the three insulins tested did not differ (t 1/2: 5.5 +/- 0.2 minutes), though acid porcine insulin exhibited lower serum peak values. The hypoglycemic effects of the three insulins were identical. Human insulin produced a significantly smaller decrease in serum potassium (2p less than 0.01). The secretion of serum C-peptide was less inhibited by human insulin (2p less than 0.05). The counter-regulatory hormonal response of cortisol and growth hormone was lower after hypoglycemia induced by human insulin (2p less than 0.05). It is suggested that the hormonal effects of hypoglycemia are modified by insulin and depend in part on the molecular structure of insulin.
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
November 1985,
Recenti progressi in medicina,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
January 1983,
Diabetes care,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
February 1984,
Acta endocrinologica,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
October 1989,
Lancet (London, England),
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
January 1991,
Clinical therapeutics,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
January 1972,
Annales d'endocrinologie,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
January 1982,
Diabetologia,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
May 1987,
International journal of clinical pharmacology, therapy, and toxicology,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
May 1974,
The Journal of clinical endocrinology and metabolism,
K J Schlüter, and
K G Petersen, and
A Borsche, and
H Hobitz, and
L Kerp
November 1988,
BMJ (Clinical research ed.),
