-transparent.png){kind=logo}
A double-blind, parallel-design multicentric study, in two phases, was conducted to examine the safety and efficacy of 2-wk treatment with various doses of beclomethasone dipropionate nasal aerosol (BDNA) and placebo in adults with seasonal allergic rhinitis. In phase I, 162 patients received BDNA, 33.5 micrograms/burst (o.d.,b.i.d., t.i.d., q.i.d.), or placebo; in phase II, 189 patients received BNDA 42, micrograms/burst (b.i.d. q.i.d.), or placebo. In both phases, statistically significant (p less than 0.05) differences favoring BDNA over placebo were found for all efficacy measures (global evaluation and total and individual symptom scores). In phase I, response to treatment increased as BDNA dosage increased, with a leveling off at t.i.d. dosage. In both phases, marked improvements were seen by week 1, with maximum improvement during week 2. Eighty-seven patients had adverse reactions-sneezing and nasal burning were most common. No suppression in morning cortisol levels was seen, nor were Candida infections promoted. A 2-wk treatment with BDNA was safe and effective in the treatment of seasonal allergic rhinitis in adults.
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
July 1982,
Annals of allergy,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
November 2013,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
September 1976,
Canadian Medical Association journal,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
June 1983,
Rhinology,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
October 2013,
Current medical research and opinion,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
March 1989,
Annals of allergy,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
January 2012,
Allergy and asthma proceedings,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
January 2016,
Allergy and asthma proceedings,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
December 1993,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
S C Siegel, and
R M Katz, and
G S Rachelefsky, and
B D Geller, and
L L Montag, and
M L Brandon, and
S J Cannon
August 2015,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
