Biomaterial Database

Hemodynamic effects of aortic occlusion during hemorrhagic shock. 1982

E L Dunn, and E E Moore, and J B Moore

We investigated cardiac dynamics following temporary aortic occlusion during profound hypovolemia and abdominal distention. Control animals (N = 10) were bled from a femoral artery catheter to a systolic blood pressure of 60 mm Hg, while simultaneous abdominal distention was effected with intraperitoneal infusion of saline. After one hour of shock, thoracic aortic occlusion and immediate laparotomy were performed. The aorta was clamped for 20 minutes and then released over 5 minutes. The second group (N = 10) underwent the same procedure but received methylprednisolone sodium succinate intravenously at the time of aortic occlusion. During hypotension, mean arterial pressure, cardiac output, stroke volume, and stroke work decreased, while systemic vascular resistance increased. Aortic occlusion improved cardiac hemodynamics in the control group; in the steroid group these changes were even more pronounced. Measurement of dp/dt demonstrated ventricular contractility impaired during hypotension and improved during the period of aortic occlusion. Temporary thoracic aortic occlusion in the face of profound hypotension and massive abdominal distention improved cardiac function. The resulting increased afterload in this hypovolemic state was without deleterious effects. Furthermore, steroids appeared to enhance the cardiac response to aortic cross-clamping.

UI	MeSH Term	Description	Entries
D007813	Laparotomy	Incision into the side of the abdomen between the ribs and pelvis.	Minilaparotomy,Laparotomies,Minilaparotomies
D008776	Methylprednisolone Hemisuccinate	A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.	Methylprednisolone Succinate,6 alpha-Methylprednisolone Sodium Hemisuccinate,A-MethaPred,Methylprednisolone Hemisuccinate Monosodium Salt,Methylprednisolone Sodium Hemisuccinate,Methylprednisolone Sodium Succinate,Solu-Medrol,Solumedrol,Urbason-Soluble,Hemisuccinate, Methylprednisolone,Sodium Hemisuccinate, Methylprednisolone,Sodium Succinate, Methylprednisolone,Succinate, Methylprednisolone,UrbasonSoluble
D003250	Constriction	The act of constricting.	Clamping,Clampings,Constrictions
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001013	Aorta, Thoracic	The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.	Aorta, Ascending,Aorta, Descending,Aortic Arch,Aortic Root,Arch of the Aorta,Descending Aorta,Sinotubular Junction,Ascending Aorta,Thoracic Aorta,Aortic Roots,Arch, Aortic,Ascending Aortas,Junction, Sinotubular,Root, Aortic,Sinotubular Junctions
D012771	Shock, Hemorrhagic	Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.	Hemorrhagic Shock