-transparent.png){kind=logo}
Retinal mean circulation time (MCT) and vascular sizes were measured in 21 normal individuals and 32 individuals with diabetes, and segmental blood flow (SBF) was calculated. The MCT was similar in the normal individuals (4.0 +/- 1.1 s) and the individuals with diabetes (4.2 +/- 1.9 s) when seven individuals with diabetes with prolonged but not quantifiable MCT were excluded. Including them by nonparametric statistics revealed that MCT was significantly longer in individuals with diabetes with proliferative retinopathy than in normal individuals or in individuals with diabetes with nonproliferative retinopathy. The prolonged MCT correlated significantly with advanced retinopathy as judged by leakage, neovascularization, and the need for photocoagulation therapy. Reduced SBF may account for the prolonged MCT, since the increase in vascular sizes observed failed to do so. However, pathologic vascular changes may alter the relation between SBF and MCT. Irrespective of implications about SBF, prolonged MCT, which indicates marked circulatory disturbance, represents an important new observation in diabetic retinopathy.
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
January 1979,
Archives of ophthalmology (Chicago, Ill. : 1960),
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
January 1974,
Revista espanola de oto-neuro-oftalmologia y neurocirugia,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
October 1965,
Investigative ophthalmology,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
July 1971,
Cardiovascular research,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
August 2020,
Investigative ophthalmology & visual science,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
February 1966,
Circulation,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
July 1958,
American journal of ophthalmology,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
January 1960,
Acta ophthalmologica,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
January 1969,
The Scientific basis of medicine annual reviews,
N P Blair, and
G T Feke, and
J Morales-Stoppello, and
C E Riva, and
D G Goger, and
G Collas, and
J W McMeel
July 1985,
Journal of pharmaceutical sciences,
