-transparent.png){kind=logo}
In an approach to characterizing the nature of the lethal event in thymineless death (TLD), rec mutants of Escherichia coli K12 were examined for their sensitivity to TLD. The recB21 and recC22 mutations sensitized cells of the AB1157 line to TLD but not cells of the HF4733 line. This increased sensitivity was not suppressed substantially by either sbcB15 or xonA1 mutation. In contrast, a recF mutation appeared to make cells more resistant to TLD than rec+ cells. Three different recA alleles were shown not to affect TLD appreciably. These results not only provide further support for the view that the site of the lethal event in TLD is cellular DNA, but also strongly suggest the involvement of the recBC and recF gene products in TLD. The apparent indifference of recA mutation implies that the conventional recombination and repair pathways per se are not involved in TLD and that the hypothetical lethal damage to DNA may be unique in nature.
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
January 1980,
Zeitschrift fur Naturforschung. Section C, Biosciences,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
January 1979,
Molecular & general genetics : MGG,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
February 1984,
Journal of bacteriology,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
March 1999,
Mutation research,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
January 1983,
Molecular & general genetics : MGG,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
November 1962,
Biochimica et biophysica acta,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
March 2010,
PLoS genetics,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
January 1977,
Zeitschrift fur Naturforschung. Section C, Biosciences,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
February 1987,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
H Nakayama, and
K Nakayama, and
R Nakayama, and
Y Nakayama
February 1965,
Proceedings of the National Academy of Sciences of the United States of America,
