-transparent.png){kind=logo}
Twenty-nine patients with Stage III and IV diffuse histiocytic lymphoma (DHL) were treated prospectively with cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone and bleomycin (CHOP-B) or hydroxydaunorubicin, cyclophosphamide, vincristine, methotrexate with leucovorine rescue and cytosine arabinoside (ACOMLA). Twenty-six evaluable patients were reclassified blindly by the Lukes-Collins classification with five large noncleaved follicular center cell (FCC), six large cleaved FCC, three large cell unclassified, seven B-immunoblastic sarcoma and five T-immunoblastic sarcoma patients identified. There was no significant survival advantage between the two combination chemotherapy programs. Survival of the immunoblastic sarcoma patients was inferior to that of the FCC lymphoma patients (P = 0.02). There were no significant survival differences between the large cleaved FCC and noncleaved FCC subtypes. Immunoblastic sarcomas, B- and T-cell types, appear to be more resistant to standard combination chemotherapy programs and new approaches may warrant more aggressive therapy in future protocols. The large cell FCC lymphomas have an excellent prognosis.
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
January 1978,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
March 1982,
Cancer,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
September 1977,
Cancer treatment reports,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
August 1979,
The New England journal of medicine,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
January 1987,
Voprosy onkologii,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
December 1979,
Blood,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
September 1979,
The New England journal of medicine,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
January 1979,
Acta radiologica: oncology, radiation, physics, biology,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
April 1996,
Cutis,
L N Newcomer, and
M I Nerenberg, and
E C Cadman, and
J A Waldron, and
L R Farber, and
J R Bertino
November 1987,
Oral surgery, oral medicine, and oral pathology,
