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Plasma aldosterone (PA) responses to sodium restriction (25 mEq sodium/day for 4 days) and to graded angiotensin II (AII) infusions (2, 4 and 8 ng/kg/min each for 30 min) during a low sodium intake were studied in 14 subjects with low renin essential hypertension (LREH) versus 16 normotensive subjects. The PA response to sodium restriction in relation to changes in plasma renin activity (PRA) was estimated by the ratio of PA increment to PRA increment after sodium restriction (delta PA/delta PRA). In 8 of 14 LREH subjects, whose delta PA/delta PRA ratios were normal, the PA responses to the graded AII doses were similar to those in the normotensive subjects. However, in the remaining 6 LREH subjects whose delta PA/delta PRA ratios were high the PA responses to the graded AII doses were greater. Apparently some LREH subjects, whose delta PA/delta PRA ratios after sodium restriction were high, have an abnormally enhanced aldosterone responsiveness to AII under the condition of low sodium intake.
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
February 1979,
The Journal of clinical endocrinology and metabolism,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
January 1988,
Journal of hypertension,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
May 1977,
Mayo Clinic proceedings,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
August 1976,
Japanese circulation journal,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
August 1975,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
November 2008,
Expert opinion on therapeutic targets,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
May 1975,
Horumon to rinsho. Clinical endocrinology,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
November 1973,
Nihon rinsho. Japanese journal of clinical medicine,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
November 1981,
La Clinica terapeutica,
R Takeda, and
S Morimoto, and
K Uchida, and
T Hashiba, and
T Kigoshi, and
A Honjo, and
A Fujimura
April 1975,
Medizinische Klinik,
