BIOMAT Database Logo BIOMAT Database Logo

The effect of dialysate sodium concentration on body fluid compartment volume, plasma renin activity and plasma aldosterone concentration in chronic hemodialysis patients. 1982

J C Van Stone, and J Bauer, and J Carey

Six stable chronic hemodialysis patients received six hemodialysis treatments: two each with the dialysate sodium concentration (DNa) 7% greater than serum sodium concentration, two with a DNa equal to serum sodium concentration and two with the DNa 7% less than the serum sodium concentration. During one treatment with each dialysate 2 kg of fluid was removed and during the other treatments the patient's weight was kept constant. Total body water (TBW), intracellular water (ICW), extracellular water (ECW), plasma volume (PV), plasma renin activity (PRA), aldosterone (ALDO), Na, BUN and osmolality were determined before and after each treatment. Fluid removal during dialysis had no effect on ICW with essentially all the fluid removed during dialysis coming from ECW. ICW increased with low DNa and decreased with high DNa. The effect of DNa on ECW and PV was the opposite of that on ICW. PRA increased and ALDO decreased during dialysis. Predialysis ALDO directly correlated with PRA (r = 0.68, p less than 0.001) but not with serum potassium concentration. Post dialysis ALDO was not significantly correlated with either PRA or potassium. Fluid removal and low DNa increased both PRA and ALDO. These studies indicate that water shifts from the extracellular space into intracellular space when DNa is lower than serum Na and the reverse is true when DNa exceeds serum Na. Plasma aldosterone decreases during dialysis despite an increase in PRA, possibly related to the decrease in serum potassium concentration. The effect of fluid removal and low DNa on PRA and ALDO may be related to a reduction in ECW and/or PV.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009994 Osmolar Concentration The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent. Ionic Strength,Osmolality,Osmolarity,Concentration, Osmolar,Concentrations, Osmolar,Ionic Strengths,Osmolalities,Osmolar Concentrations,Osmolarities,Strength, Ionic,Strengths, Ionic
D010953 Plasma Volume Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES. Blood Plasma Volume,Blood Plasma Volumes,Plasma Volumes,Volume, Blood Plasma,Volume, Plasma,Volumes, Blood Plasma,Volumes, Plasma
D012083 Renin A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19. Angiotensin-Forming Enzyme,Angiotensinogenase,Big Renin,Cryorenin,Inactive Renin,Pre-Prorenin,Preprorenin,Prorenin,Angiotensin Forming Enzyme,Pre Prorenin,Renin, Big,Renin, Inactive
D001825 Body Fluid Compartments The two types of spaces between which water and other body fluids are distributed: extracellular and intracellular. Body Fluid Compartment,Compartment, Body Fluid,Compartments, Body Fluid,Fluid Compartment, Body,Fluid Compartments, Body
D001826 Body Fluids Liquid components of living organisms. Body Fluid,Fluid, Body,Fluids, Body
D005260 Female Females
D006435 Renal Dialysis Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION. Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

J C Van Stone, and J Bauer, and J Carey
Effect of sodium dialysate concentration on the extracellular fluid distribution during hemodialysis.
January 1984, Contributions to nephrology,
J C Van Stone, and J Bauer, and J Carey
The effect of extremely high sodium intake on plasma renin activity, plasma aldosterone concentration, and urinary excretion of aldosterone metabolites.
May 1979, The Journal of laboratory and clinical medicine,
J C Van Stone, and J Bauer, and J Carey
Effect of aging and sodium deprivation on plasma concentration of aldosterone and on plasma renin activity in the rat.
January 1996, Gerontology,
J C Van Stone, and J Bauer, and J Carey
Plasma renin activity in relation to serum sodium concentration and body fluid balance.
December 1968, The Journal of clinical endocrinology and metabolism,
J C Van Stone, and J Bauer, and J Carey
Effects of hemodialysis and saline loading on body fluid compartments, plasma renin activity and blood pressure in patients on chronic hemodialysis.
January 1977, Nephron,
J C Van Stone, and J Bauer, and J Carey
Effects of sodium loading, sodium depletion and posture on plasma aldosterone concentration and renin activity in hypertensive patients.
October 1969, The Journal of clinical endocrinology and metabolism,
J C Van Stone, and J Bauer, and J Carey
Effect of dialysate sodium concentration on sodium gradient and hemodialysis parameters.
December 2014, Electrolyte & blood pressure : E & BP,
J C Van Stone, and J Bauer, and J Carey
Effect of acute volume depletion on blood pressure, plasma renin activity and plasma aldosterone concentration in hypertensive subjects.
May 1975, Japanese circulation journal,
J C Van Stone, and J Bauer, and J Carey
[Study on renin-angiotensin-aldosterone system. II. Changes of plasma renin activity, plasma aldosterone concentration and urinary sodium excretion in the hypertensives].
February 1984, Nihon Jinzo Gakkai shi,
J C Van Stone, and J Bauer, and J Carey
[Plasma aldosterone and plasma renin activity during hemodialysis].
January 1973, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
Copied contents to your clipboard!