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Eighteen patients with Stage III or IV nodular poorly differentiated lymphocytic lymphoma (malignant lymphoma, infiltrative nodular type, with predominately small cleaved cells) were treated with intermittent high-dose oral chlorambucil (16 mg/m2 daily for five consecutive days each month) for one year. Complete clinical remissions occurred in 78% of these patients and partial remissions in another 17%. Complete remission usually occurred within three months of beginning therapy and with a medial follow-up of 35 months no patient has relapsed. Toxicity, usually hematologic and occurring late in therapy, has been mild, necessitating termination of therapy in only one patient. Review of recent therapy fails to demonstrate a definite long-term advantage of more aggressive treatment regimens. Intermittent high-dose chlorambucil should be further evaluated as therapy for nodular poorly differentiated lymphocytic lymphoma.
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
December 1992,
Missouri medicine,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
January 1981,
Cancer treatment reports,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
August 1984,
Blood,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
June 1985,
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E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
May 1978,
Cancer,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
August 1981,
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E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
February 1986,
American journal of clinical oncology,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
October 1979,
The Journal of dermatology,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
August 1979,
Cancer research,
E Cadman, and
F Drislane, and
J A Waldron, and
L Farber, and
L Prosnitz, and
J R Bertino
January 1981,
Journal of oral medicine,
