Biomaterial Database

Thialysine utilization by E. coli and its effects on cell growth. 1982

M Di Girolamo, and V Busiello, and C Cini, and C Foppoli, and C De Marco

Thialysine can be utilized for growth by a wild type K12 strain of E. coli. It is incorporated into proteins in substitution and in competition with lysine; up to 17% of protein lysine can be substituted by thialysine. Nevertheless the presence of thialysine in the culture medium gives rise to an inhibition of cell growth rate. This effect has been correlated to the inhibition of protein synthesis rate by thialysine and to the extent of protein lysine substitution by the analog. On the other hand this substitution does not affect cell viability.

UI	MeSH Term	Description	Entries
D003545	Cysteine	A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.	Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D004926	Escherichia coli	A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.	Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D001426	Bacterial Proteins	Proteins found in any species of bacterium.	Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial