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The uridine analog 3-deazauridine has been given to 19 patients in a phase I and pharmacokinetic study. Only mild toxicity was seen at doses less than 1200 mg/m2/day for 5 days. At a dose of 1200 mg/m2/day x 5, leukopenia (mean wbc count nadir of 2650/mm3) was seen in nine of 12 patients and thrombocytopenia (mean platelet count nadir of 47,000/mm3) in five of 12 patients. Nausea and vomiting and oral toxicity were each seen in two patients, and diarrhea and skin toxicity occurred in one patient each. Pharmacokinetic studies indicate a biphasic plasma decay with a beta-half-life of 6.9 hours and urinary excretion, mostly of unchanged drug, as the most important route for drug elimination. A dose of 1200 mg/m2/day x 5 is recommended for phase II studies and great caution is advised in administering the drug in the presence of renal impairment.
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
October 1984,
American journal of clinical oncology,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
January 1982,
Cancer treatment reports,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
August 1990,
Investigational new drugs,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
April 1993,
Anti-cancer drugs,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
April 1994,
Anti-cancer drugs,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
June 2000,
Clinical cancer research : an official journal of the American Association for Cancer Research,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
January 1996,
Investigational new drugs,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
January 2002,
Clinical cancer research : an official journal of the American Association for Cancer Research,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
January 1990,
Cancer chemotherapy and pharmacology,
P J Creaven, and
R L Priore, and
A Mittelman, and
S Bruno, and
E S Henderson, and
Y M Rustum, and
J K Solomon
January 1981,
Cancer treatment reports,
