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In 200 patients with suspected MS, the diagnostic value of VEP elicited by checkerboard reversal and central foveal stimulation was compared. No significant difference was evident, but both methods overlap. The more stable checkerboard reversal stimulation should be preferred as a diagnostic method. Only in suspected MS with normal checkerboard responses, additional foveal responses may give supplementary information. Normal VEPs cannot exclude a prior retrobulbar neuritis.
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