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Prostaglandins, or related compounds, as well as estrogen and androgen are believed to be involved in the processes that lead to the development of murine lupus erythematosus (LE) in NZB/NZW F1 hybrid mice. In this investigation we measured NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) activity in kidney tissue of male and female NZB/NZW F1 hybrid mice and in kidney tissue of male and female mice of other strains. In each case the specific activity of PGDH was significantly greater in kidney tissue of male than in kidney tissue of female mice. However, the specific activities of PGDH in kidney tissues of males of various strains of mice were similar, and the specific activities of PGDH in kidney tissues of females of various strains-including the NZB/NZW F1 hybrid- were similar. Thus, while the lower activity of PGDH in kidney tissues of the female may be important in the pathogenesis of LE, the lower activity of this enzyme is not unique to the kidney of the female NZB/NZW F1 hybrid mouse.
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
January 1980,
Prostaglandins,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
May 1980,
Analytical biochemistry,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
August 1990,
Biochimica et biophysica acta,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
July 1985,
Pflugers Archiv : European journal of physiology,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
February 1979,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
July 1980,
Biochimica et biophysica acta,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
April 1987,
Nihon Sanka Fujinka Gakkai zasshi,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
January 1982,
Methods in enzymology,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
September 1984,
Early human development,
M L Casey, and
E R Hurd, and
J N Gilliam, and
P C MacDonald, and
J M Johnston
January 1986,
Clinical and experimental hypertension. Part A, Theory and practice,
