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Biopsy specimens of the duodenal mucosa were assayed to determine their secretin-like activity in 9 controls, 9 patients with gastric ulcer, 19 patients with duodenal ulcer, 4 patients with gastric and duodenal ulcer, and 13 patients with chronic pancreatitis. The bioassay of secretin was done on the pancreatic secretion in anesthetized rats. The sensitivity was in the orcer of 0.0625 CHR unit/rat (4 ng/rat). In the range between 0.0625 and 0.5 CHR units a satisfactory dose dependency was recognized. The following results were obtained. 1) The level of duodenal mucosal secretin-like activity in patients with gastric ulcer was the same as that in the controls, but was elevated in 32% of the patients with duodenal ulcer, 50% of those with gastric and duodenal ulcer, and 8% of those with chronic pancreatitis. 2) The high level of secretin-like activity noted in patients with duodenal ulcer was suspected to be related to the hypersecretion of gastric acid which is characteristic of this disease, but there was no correlation between gastric acid secretion and secretin-like activity in the duodenal mucosa.
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
T Kamei, and
M Hanawa, and
S Takahashi, and
K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
January 1975,
Gastroenterologia Japonica,
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
T Kamei, and
M Hanawa, and
S Takahashi, and
K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
January 1978,
Gastroenterologia Japonica,
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
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K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
June 1985,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
T Takebe, and
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T Kamei, and
M Hanawa, and
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K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
October 1978,
Horumon to rinsho. Clinical endocrinology,
T Takebe, and
S Ishizuki, and
T Kagaya, and
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T Kamei, and
M Hanawa, and
S Takahashi, and
K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
June 1969,
The American journal of gastroenterology,
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
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S Takahashi, and
K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
January 1975,
Przeglad lekarski,
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
T Kamei, and
M Hanawa, and
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K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
March 1965,
Terapevticheskii arkhiv,
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
T Kamei, and
M Hanawa, and
S Takahashi, and
K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
November 1985,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
T Kamei, and
M Hanawa, and
S Takahashi, and
K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
January 1978,
Scandinavian journal of gastroenterology,
T Takebe, and
S Ishizuki, and
T Kagaya, and
M Koizumi, and
S Kataoka, and
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M Hanawa, and
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K Ohyama, and
K Endo, and
M Mita, and
A Ishimori
May 1982,
Gut,
