Biomaterial Database

Acid secretion and duodenal ulcer healing in patients on medical treatment. 1982

I B Angorn, and M G Moshal

The relationship between gastric acid secretion and ulcer healing was analysed in 168 patients with endoscopically proven duodenal ulceration. One hundred and three patients received active treatment with various therapeutic agents and 65 received placebo. The mean maximal acid output in patients with unhealed ulcers was significantly higher than that in patients with endoscopically confirmed ulcer healing in both the actively treated and the placebo groups (P less than 0,001). In patients with normosecretory acid status the rate of ulcer healing on active treatment was significantly higher than that achieved with placebo (P less than 0,001). However, no significant difference in ulcer healing was evident following active treatment or placebo administration in patients with hypersecretion of acid. Acid secretory profiles warrant consideration when the results of clinical trials are interpreted.

UI	MeSH Term	Description	Entries
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004381	Duodenal Ulcer	A PEPTIC ULCER located in the DUODENUM.	Curling's Ulcer,Curling Ulcer,Curlings Ulcer,Duodenal Ulcers,Ulcer, Curling,Ulcer, Duodenal,Ulcers, Duodenal
D005744	Gastric Acid	Hydrochloric acid present in GASTRIC JUICE.	Hydrochloric Acid, Gastric,Acids, Gastric,Acids, Gastric Hydrochloric,Gastric Acids,Gastric Hydrochloric Acid,Gastric Hydrochloric Acids,Hydrochloric Acids, Gastric
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings