Biomaterial Database

The use of human placental lactogen, oxytocinase and estriol in twin pregnancies with intrauterine growth retardation. 1982

J W Briët, and R K Hoorn

In 38 twin pregnancies human placental lactogen (HPL) and oxytocinase were measured in serum and estriol in urine. Eleven women carried light-for-dates (LFD) twins (birth weight less than P5), and 27 had appropriate-for-dates twins (birth weight greater than P5). We investigated if intrauterine growth retardation in these patients could be detected either by the biochemical measurements of by clinical examination. The values of oxytocinase and estriol were not related to fetal weight. A serum level of HPL of 12 mg/l after 34 wk of gestation proved to be helpful in the detection of LFD twins. The predictive value of a positive test was 64% (7/11) and of a negative test 84% (21/25). Eight LFD twins were suspected clinically. If clinical examination and HPL measurements were used in conjunction all LFD twins could have been suspected before birth.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007236	Infant, Small for Gestational Age	An infant having a birth weight lower than expected for its gestational age.
D010122	Cystinyl Aminopeptidase	A zinc-containing sialoglycoprotein that is used to study aminopeptidase activity in the pathogenesis of hypertension. EC 3.4.11.3.	Cystine Arylamidase,Cystyl Aminopeptidase,Oxytocinase,Cystidyl Aminopeptidase,Cystinaminopeptidase,Cystine Aminopeptidase,Vasopressinase
D010928	Placental Lactogen	A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.	Choriomammotropin,Chorionic Somatomammotropin, Human,Human Placental Lactogen,Lactogen Hormone, Placental,Mammotropic Hormone, Placental,Somatomammotropin, Chorionic,Choriomammotrophin,HCS (Human Chorionic Somatomammotropin),HPL (Human Placental Lactogen),PAPP-D,Placental Luteotropin,Pregnancy-Associated Plasma Protein D,Chorionic Somatomammotropin,Human Chorionic Somatomammotropin,Lactogen, Placental,Luteotropin, Placental,Placental Lactogen, Human,Placental Mammotropic Hormone,Pregnancy Associated Plasma Protein D
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011272	Pregnancy, Multiple	The condition of carrying two or more FETUSES simultaneously.	Multiple Pregnancy,Multiple Pregnancies,Pregnancies, Multiple
D011296	Prenatal Diagnosis	Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.	Diagnosis, Prenatal,Fetal Diagnosis,Fetal Imaging,Fetal Screening,Intrauterine Diagnosis,Antenatal Diagnosis,Antenatal Screening,Diagnosis, Antenatal,Diagnosis, Intrauterine,Prenatal Screening,Antenatal Diagnoses,Antenatal Screenings,Diagnosis, Fetal,Fetal Diagnoses,Fetal Imagings,Fetal Screenings,Imaging, Fetal,Intrauterine Diagnoses,Prenatal Diagnoses,Prenatal Screenings,Screening, Antenatal,Screening, Fetal,Screening, Prenatal
D004964	Estriol	A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.	(16alpha,17beta)-Estra-1,3,5(10)-Triene-3,16,17-Triol,(16beta,17beta)-Estra-1,3,5(10)-Triene-3,16,17-Triol,16-alpha-Hydroxy-Estradiol,16alpha,17beta-Estriol,16beta-Hydroxy-Estradiol,Epiestriol,Estra-1,3,5(10)-Triene-3,16beta,17beta-Triol,Ovestin,16 alpha Hydroxy Estradiol,16alpha,17beta Estriol,16beta Hydroxy Estradiol
D005260	Female		Females
D005317	Fetal Growth Retardation	Failure of a FETUS to attain expected GROWTH.	Growth Retardation, Intrauterine,Intrauterine Growth Retardation,Fetal Growth Restriction,Intrauterine Growth Restriction