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Effect of calcium on sulfated mucous glycoprotein secretion in dog trachea. 1982

M G Marin, and J A Estep, and J P Zorn

In this experiment utilizing dog trachea we determined the effect of calcium concentration in the bathing media on the kinetics of secretion of sulfate incorporated into mucous glycoprotein. The results showed that in eight tracheas the secretion rate of 269 +/- 65 pmol SO4 . cm-2 . hr-1 (mean +/- SE) of tissues bathed in solution lacking calcium throughout the experiment was significantly less than the rate of 526 +/- 87 pmol SO4 . cm-2 . hr-1 of tissues bathed in solution containing 1.9 mM Ca2+. When tissues bathed in 1.9 mM CA2+ were incubated with 35SO4 to a constant secretion rate and then placed in 0 mM Ca2+ solution, the secretion of incorporated sulfate was unchanged relative to tissues bathed 1.9 mM Ca2+ throughout the experiment. Pool size of 727 +/- 150 pmol SO4/cm2 in tissues incubated in 0 mM Ca2+ throughout the experiment was significantly less than the pool size of 1,069 +/- 190 pmol SO4/cm2 in 1.9 mM Ca2+ solutions. This study showed that either the uptake of sulfate and/or biosynthetic pool size of sulfate incorporated into mucous glycoproteins was decreased in solution lacking calcium. However, release of sulfate incorporated into mucous glycoprotein in the lumen was independent of calcium in the external bathing media.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009092 Mucous Membrane An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa. Lamina Propria,Mucosa,Mucosal Tissue,Muscularis Mucosae,Mucous Membranes,Membrane, Mucous,Membranes, Mucous,Mucosae, Muscularis,Mucosal Tissues,Propria, Lamina,Tissue, Mucosal,Tissues, Mucosal
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004594 Electrophysiology The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
D006023 Glycoproteins Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins. C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013431 Sulfates Inorganic salts of sulfuric acid. Sulfate,Sulfates, Inorganic,Inorganic Sulfates
D013462 Sulfur Radioisotopes Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes. Radioisotopes, Sulfur
D014132 Trachea The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Tracheas

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