The dexamethasone suppression test as a diagnostic aid in late onset paranoia. 1982

N G Ward, and M M Strauss, and R Ries

A case of acute paranoia in a 64-year-old woman with a previous history of one depressive episode is described. Accurate diagnosis was hampered by her illogical and tangential answers to questions and the development of an organic brain syndrome while on neuroleptics and anticholinergics. She did not tolerate tricyclic antidepressants and was unresponsive to three electroconvulsive therapy (ECT) treatments. Because of the previous history of depression and the presence of some depressive symptoms, the possibility of a depression underlying her paranoid psychosis was considered. A dexamethasone suppression test (DST) was performed to confirm this and was found to be abnormal. ECT was then continued with the eventual result of complete remission in symptoms. The authors discuss the potential usefulness of the DST in confirming a diagnosis of depression in selected cases of late onset psychosis.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010259 Paranoid Disorders Chronic mental disorders in which there has been an insidious development of a permanent and unshakeable delusional system (persecutory delusions or delusions of jealousy), accompanied by preservation of clear and orderly thinking. Emotional responses and behavior are consistent with the delusional state. Paranoia,Paranoid Psychoses,Psychoses, Paranoid,Disorder, Paranoid,Disorders, Paranoid,Paranoias,Paranoid Disorder
D003866 Depressive Disorder An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. Depression, Endogenous,Depression, Neurotic,Depression, Unipolar,Depressive Syndrome,Melancholia,Neurosis, Depressive,Unipolar Depression,Depressions, Endogenous,Depressions, Neurotic,Depressions, Unipolar,Depressive Disorders,Depressive Neuroses,Depressive Neurosis,Depressive Syndromes,Disorder, Depressive,Disorders, Depressive,Endogenous Depression,Endogenous Depressions,Melancholias,Neuroses, Depressive,Neurotic Depression,Neurotic Depressions,Syndrome, Depressive,Syndromes, Depressive,Unipolar Depressions
D003907 Dexamethasone An anti-inflammatory 9-fluoro-glucocorticoid. Hexadecadrol,Decaject,Decaject-L.A.,Decameth,Decaspray,Dexasone,Dexpak,Hexadrol,Maxidex,Methylfluorprednisolone,Millicorten,Oradexon,Decaject L.A.
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol

Related Publications

N G Ward, and M M Strauss, and R Ries
September 1979, The American journal of psychiatry,
N G Ward, and M M Strauss, and R Ries
October 1982, Nederlands tijdschrift voor geneeskunde,
N G Ward, and M M Strauss, and R Ries
January 1983, Journal of the American Geriatrics Society,
N G Ward, and M M Strauss, and R Ries
January 1986, International journal of psychiatry in medicine,
N G Ward, and M M Strauss, and R Ries
February 1983, Annales medico-psychologiques,
N G Ward, and M M Strauss, and R Ries
May 1987, Biological psychiatry,
N G Ward, and M M Strauss, and R Ries
September 1980, Lancet (London, England),
N G Ward, and M M Strauss, and R Ries
January 1956, Rivista di patologia nervosa e mentale,
N G Ward, and M M Strauss, and R Ries
September 1983, Journal of the American Academy of Child Psychiatry,
N G Ward, and M M Strauss, and R Ries
January 1988, Psychiatrie, Neurologie und medizinische Psychologie. Beihefte,
Copied contents to your clipboard!