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A method is described for the determination of meperidine and its pharmacologically active metabolite, normeperidine, in blood, plasma, and urine using gas chromatography with nitrogen-phosphorus detection. Structural analogs of both meperidine and normeperidine were used as internal standards. Unlike previously reported assays, this procedure was sensitive and convenient enough for use in pharmacokinetic studies of both meperidine and normeperidine following single doses of meperidine. The assay was sensitive to 5 ng of meperidine/ml and 2.5 ng of normeperidine/ml extracted from a 1-ml biological sample. The between-assay coefficients of variation at these concentrations were 9.4 and 10.4%, respectively.
P Jacob, and
J F Rigod, and
S M Pond, and
N L Benowitz
October 1976,
Journal of chromatography,
P Jacob, and
J F Rigod, and
S M Pond, and
N L Benowitz
January 1978,
Journal of forensic sciences,
P Jacob, and
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N L Benowitz
January 1997,
Fa yi xue za zhi,
P Jacob, and
J F Rigod, and
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N L Benowitz
April 1975,
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P Jacob, and
J F Rigod, and
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N L Benowitz
December 1989,
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P Jacob, and
J F Rigod, and
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N L Benowitz
October 1984,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
P Jacob, and
J F Rigod, and
S M Pond, and
N L Benowitz
January 1988,
Journal of perinatology : official journal of the California Perinatal Association,
P Jacob, and
J F Rigod, and
S M Pond, and
N L Benowitz
April 1979,
American journal of obstetrics and gynecology,
P Jacob, and
J F Rigod, and
S M Pond, and
N L Benowitz
January 1962,
Anesthesiology,
P Jacob, and
J F Rigod, and
S M Pond, and
N L Benowitz
October 1982,
The Journal of pharmacology and experimental therapeutics,
