[Acute arsenious hydride intoxication. Four cases (author's transl)]. 1982

B Gosselin, and D Mathieu, and M Desprez-Nolf, and A Cosson, and J Goudemand, and J M Haguenoer, and F Wattel

While engaged in the repair of a zinc furnace, 4 workers were accidentally exposed to arsenious hydride (AsH3) fumes. Acute intravascular haemolysis developed within a few hours. On admission, the patients immediately underwent exsanguino-transfusion; 8.2 to 10.2 l of blood were exchanged through a continuous perfusion pump at the rate of 1 l/hour. Two patients resumed diuresis during transfusion, but the other two required repeated haemodialysis. Between the 10th and 30th days, while renal function was gradually returning to normal, mildly megaloblastic anaemia developed. This was followed during the 3rd month by clinical and electric signs of polyneuritis of the lower and upper limbs, which subsequently regressed. Regular measurements of arsenic levels in the blood and urine were performed between and during exsanguino-transfusion and haemodialysis.

UI MeSH Term Description Entries
D006461 Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity. Haemolysis,Extravascular Hemolysis,Intravascular Hemolysis,Extravascular Hemolyses,Haemolyses,Hemolyses, Extravascular,Hemolyses, Intravascular,Hemolysis, Extravascular,Hemolysis, Intravascular,Intravascular Hemolyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000393 Air Pollutants Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or materials. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS. Air Pollutant,Air Pollutants, Environmental,Environmental Air Pollutants,Environmental Pollutants, Air,Air Environmental Pollutants,Pollutant, Air,Pollutants, Air,Pollutants, Air Environmental,Pollutants, Environmental Air
D000395 Air Pollutants, Occupational Toxic air-borne matter related to work performed They are usually produced by the specific nature of the occupation. Occupational Air Pollutants,Pollutants, Occupational Air
D001151 Arsenic A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed) Arsenic-75,Arsenic 75
D001152 Arsenicals Inorganic or organic compounds that contain arsenic. Arsenic Compounds,Compounds, Arsenic
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D020261 Arsenic Poisoning Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212) Arsenic Encephalopathy,Arsenic Induced Polyneuropathy,Arsenic Poisoning, Inorganic,Arsenic Poisoning, Nervous System,Arsenic Poisoning, Organic,Encephalopathy, Arsenic,Inorganic Arsenic Poisoning,Nervous System Poisoning, Arsenic,Nervous System, Organic Arsenic Poisoning,Neurotoxicity Syndrome, Arsenical,Organic Arsenic Poisoning, Nervous System,Poisoning, Arsenic, Nervous System,Polyneuropathy, Arsenic-Induced,Arsenic Encephalopathies,Arsenic Poisonings,Arsenic Poisonings, Inorganic,Arsenic Poisonings, Organic,Arsenic-Induced Polyneuropathies,Arsenic-Induced Polyneuropathy,Arsenical Neurotoxicity Syndrome,Arsenical Neurotoxicity Syndromes,Encephalopathies, Arsenic,Inorganic Arsenic Poisonings,Neurotoxicity Syndromes, Arsenical,Organic Arsenic Poisoning,Organic Arsenic Poisonings,Poisoning, Arsenic,Poisoning, Inorganic Arsenic,Poisoning, Organic Arsenic,Poisonings, Arsenic,Poisonings, Inorganic Arsenic,Poisonings, Organic Arsenic,Polyneuropathy, Arsenic Induced,Syndrome, Arsenical Neurotoxicity,Syndromes, Arsenical Neurotoxicity

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