[Thiazolidine carboxylic acid toxicity. A review of 78 cases (author's transl)]. 1982

M L Efthymiou, and J Jouglard

Among the calls for information recently received by the French Poison Control Centers, 78 concerned a liver protecting agent, thiazolidine carboxylic acid. In almost every case, doses well above the therapeutic range have provided a status epilepticus. Thus confirming the neurotoxicity of the drug which had been known to the Poison control Centers for the past 10 years. Several patients had also metabolic acidosis, severe hypoglycaemia, or, more scarcely, hyperglycaemia. Seizures convulsions occurred specially in young children whose immature blood-brain barrier allowed penetration into the CSF of thiazolidine carboxylic acid, later metabolized locally into the strongly irritant compound formaldehyde. In view of its toxicity, the drug should never be administered to young children. The usual measures to prevent intoxication should be applied and in case of overdosage the patients should be admitted to hospital for observation. Long-lasting anti-epileptic treatments should be avoided.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

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