Biomaterial Database

Aberrations of circadian body temperature rhythms in rats with medial preoptic lesions. 1982

E Satinoff, and J Liran, and R Clapman

The normal amplitude of the circadian rhythm of telemetered body temperature (Tb) in male rats was 2 degrees C (between 36 and 38 degrees C). For several weeks after large medial preoptic lesions Tb cycled from as low as 29 degrees C to as high as 41 degrees C in a single day. With recovery, or in rats with smaller lesions, peak-to-trough Tb amplitudes decreased, ranging between 3 and 5 degrees C for many months, with normal or slightly raised troughs in the light part and grossly higher peaks in the dark part of a 12:12 light-dark cycle. Rats in whom some periventricular tissue was spared had normal amplitudes of Tb, but the whole curve was displaced 0.5-1.0 degrees C above control values. These effects persisted in constant darkness. We conclude that in the weeks after medial preoptic lesions thermoregulatory responses are not activated until Tb is abnormally high or low. As recovery progresses, or if the lesions are smaller to begin with, there may be an imbalance between heat loss and heat production systems so that heat production mechanisms are either always dominant or overshoot when activated.

UI	MeSH Term	Description	Entries
D007031	Hypothalamus	Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.	Lamina Terminalis,Preoptico-Hypothalamic Area,Area, Preoptico-Hypothalamic,Areas, Preoptico-Hypothalamic,Preoptico Hypothalamic Area,Preoptico-Hypothalamic Areas
D007033	Hypothalamus, Middle	Middle portion of the hypothalamus containing the arcuate, dorsomedial, ventromedial nuclei, the TUBER CINEREUM and the PITUITARY GLAND.	Hypothalamus, Medial,Intermediate Hypothalamic Region,Hypothalamic Region, Intermediate,Hypothalamic Regions, Intermediate,Intermediate Hypothalamic Regions,Medial Hypothalamus,Middle Hypothalamus,Region, Intermediate Hypothalamic,Regions, Intermediate Hypothalamic
D008297	Male		Males
D001833	Body Temperature Regulation	The processes of heating and cooling that an organism uses to control its temperature.	Heat Loss,Thermoregulation,Regulation, Body Temperature,Temperature Regulation, Body,Body Temperature Regulations,Heat Losses,Loss, Heat,Losses, Heat,Regulations, Body Temperature,Temperature Regulations, Body,Thermoregulations
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013686	Telemetry	Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Telemetries
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus