-transparent.png){kind=logo}
In stroke-prone spontaneously hypertensive rats (SHRSP) and in normotensive Wistar-Kyoto rats (WKY), arginine vasopressin (AVP) was measured by means of a radioimmunoassay in the plasma, the pituitary gland, the hypothalamus, and the brain stem. In 6- and 14-wk-old SHRSP, the plasma concentration of AVP was lower than in age-matched WKY (P less than 0.01), whereas it was elevated at 28 wk of age (P less than 0.01). In the pituitary of 6-wk-old SHRSP, AVP was higher than in WKY (P less than 0.05), but no such difference was found in older rats. In the hypothalamus and the brain stem, AVP content was reduced in all age groups of SHRSP. Plasma osmolality was diminished in 28-wk-old SHRSP only (P less than 0.01), whereas hematocrit in all age groups was higher in SHRSP than in WKY. It is concluded that the secretion of AVP and possibly its synthesis in the hypothalamus are reduced in SHRSP. Whether the reduced AVP content in the brain stem is related to the sustained elevation of blood pressure has to be studied further.
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
January 1989,
Acta physiologica Polonica,
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
January 1993,
Journal of hypertension,
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
January 1984,
Hypertension (Dallas, Tex. : 1979),
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
June 1983,
Neuroendocrinology,
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
December 1994,
The American journal of physiology,
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
September 1993,
Hypertension (Dallas, Tex. : 1979),
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
November 1987,
Hypertension (Dallas, Tex. : 1979),
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
September 1981,
Clinical science (London, England : 1979),
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
January 1991,
Clinical and experimental hypertension. Part A, Theory and practice,
W Rascher, and
R E Lang, and
T Unger, and
D Ganten, and
F Gross
June 1986,
Hypertension (Dallas, Tex. : 1979),
