Biomaterial Database

Differential effects of histamine on protein permeability in dog lung and forelimb. 1982

M B Maron

In this study, the effects of histamine on the microvascular permeability of a canine, isolated perfused left lower lung lobe (LLL) and a forelimb preparation were evaluated by comparing the apparent filtered volumes (VF) calculated from the increases in hematocrit (Hct) and plasma protein concentration (Pr) observed during filtration. In the LLL and forelimb, the elevation of venous pressure (Pv) to 15.5 Torr resulted in a ratio of filtered volumes (VF,Pr/VF,Hct) of 0.97 and 0.99, respectively. In the LLL, histamine administration did not significantly change this ratio, whereas the addition of methylene blue decreased it to 0.62. In the forelimb, histamine transiently decreased VF,Pr/VF,Hct to 0.23. After recovery, the elevation of Pv to cause further filtration resulted in a ratio of 0.94. These data suggest that intrinsic differences in the regulation of microvascular permeability exist between blood vessels of the lung and forelimb, in that a histamine dose that significantly increased the protein permeability of the forelimb had no measurable effect on the LLL.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008833	Microcirculation	The circulation of the BLOOD through the MICROVASCULAR NETWORK.	Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D010539	Permeability	Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.	Permeabilities
D011652	Pulmonary Circulation	The circulation of the BLOOD through the LUNGS.	Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D001798	Blood Proteins	Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.	Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D001810	Blood Volume	Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.	Blood Volumes,Volume, Blood,Volumes, Blood
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005552	Forelimb	A front limb of a quadruped. (The Random House College Dictionary, 1980)	Forelimbs
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell