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The use of topical mechlorethamine hydrochloride in the treatment of skin disease has been restricted because of the frequent development of contact dermatitis. A series of 24 patients with mycosis fungoides in stages 1A (eight patients), 1B (15 patients), and 2 (one patient) were treated with ointment-based mechlorethamine, prepared by an anhydrous method. This preparation was therapeutically effective. Complete clearing occurred in 15 of 18 patients with active disease over evaluation periods of up to 27 months, and one patient had partial clearing. Two patients showed a partial relapse during their evaluation periods. The incidence of contact dermatitis was very low: 8% in individuals with a history of hypersensitivity to mechlorethamine and 0% in patients being exposed to the medication for the first time. This new preparation has been shown to be effective therapy for mycosis fungoides. Patient use is associated with minimal side effects.
N M Price, and
D G Deneau, and
R T Hoppe
November 1992,
Journal of the American Academy of Dermatology,
N M Price, and
D G Deneau, and
R T Hoppe
November 1977,
The British journal of dermatology,
N M Price, and
D G Deneau, and
R T Hoppe
November 1972,
JAMA,
N M Price, and
D G Deneau, and
R T Hoppe
December 1984,
Archives of dermatology,
N M Price, and
D G Deneau, and
R T Hoppe
December 1977,
Cancer,
N M Price, and
D G Deneau, and
R T Hoppe
October 1988,
Journal of the American Academy of Dermatology,
N M Price, and
D G Deneau, and
R T Hoppe
January 1983,
Cleveland Clinic quarterly,
N M Price, and
D G Deneau, and
R T Hoppe
October 2006,
Journal of drugs in dermatology : JDD,
N M Price, and
D G Deneau, and
R T Hoppe
March 1982,
Archives of dermatology,
N M Price, and
D G Deneau, and
R T Hoppe
March 2022,
Dermatology and therapy,
