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Compounds having 2-methoxynaphthalene as their parent nucleus were synthesized and evaluated for antiinflammatory effect according to the carrageenin paw edema method in rats. The synthetic routes for the preparation of isomeric 1,2- and 2,6-disubstituted derivatives are described. Replacement of the alpha-methylacetic moiety in naproxen by 4-hydroxybutyric acid side chain did not cause loss of activity.
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