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Serum theophylline levels were compared after the administration of a sustained-release (Theo-Dur, Key Pharmaceuticals, USA) vs. a rapid-release (Glyphyllin, Ikapharm, Israel) theophylline preparation to 24 children suffering from chronic bronchial asthma. They received each of the two drugs for a 5-d period, and serum theophylline levels were determined on the 6th d. Therapeutic serum levels were achieved in 66.6 and 75% of the patients receiving sustained-release and rapid-release theophylline preparations, respectively. The peak-trough difference for the rapid-release drug was higher than that of the sustained-release preparations (5.5 +/- 2.6 micrograms/ml vs. 2.6 +/- 2.3 micrograms/ml). Both drugs caused nearly the same low percentage of side effects (15 and 16.6%). A noncompliance rate of 16.6% was found with the rapid-release drug, and all the parents preferred the sustained-release drug is preferable for chronic treatment of children with bronchial asthma, as it maintains more stable serum theophylline levels and has a higher compliance rate.
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
December 1979,
American journal of hospital pharmacy,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
January 1984,
The Journal of asthma : official journal of the Association for the Care of Asthma,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
November 1985,
The Journal of pediatrics,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
January 1987,
International journal of clinical pharmacology research,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
February 1985,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
July 1980,
Pediatrics,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
April 1986,
American journal of diseases of children (1960),
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
January 1979,
The Journal of international medical research,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
August 1984,
International journal of clinical pharmacology, therapy, and toxicology,
S Beer, and
J Laver, and
L Benson, and
D Cotariu, and
P Neli, and
J L Saidman, and
E Viure
December 1978,
Archives of disease in childhood,
