-transparent.png){kind=logo}
A pedigree showing the fragile site at Xq27 in a severely retarded female and in other less retarded carriers is described. Two of the four moderately retarded males with the fra(X)(q27) show macro-orchidism, and a variety of other features usually used to support the effects of the fra(X)(q27) are also inconsistent. A second fragile site at (10)(q23) is also present and in the two oldest females its frequency is not decreased, whereas the fra(x)(q27) is not detectable in these females although probably present. It is concluded that pedigrees showing mentally retarded females and probable X linkage should be included in studies of the fra(X)(q27).
Related Publications
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
January 1981,
Human genetics,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
January 1979,
Human genetics,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
December 2011,
Rheumatology (Oxford, England),
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
January 1980,
American journal of medical genetics,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
January 1990,
American journal of mental retardation : AJMR,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
March 1990,
Archives of disease in childhood,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
September 1989,
Archives of disease in childhood,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
April 1981,
Deutsche medizinische Wochenschrift (1946),
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
November 2011,
Biological psychiatry,
G C Webb, and
J L Halliday, and
D B Pitt, and
C G Judge, and
M Leversha
October 1982,
American journal of medical genetics,
