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The exposure of rats to hypokinesia and a phosphorus-enriched diet (Ca : P = 1:3) was accompanied by hypocalciemia, hyperphosphatemia, calcium losses from bones and formation of calcificates in the kidneys. The decrease of the phosphorus content in the diet (Ca : P = 1:0.5--1:1) prevented these disorders. The administration of 1 alpha OHD3 at a dose of 0.025 microgram/day arrested hypokinesia-associated hypocalciemia and bone changes. The administration of 1 alpha OHD3 together with a high phosphorus consumption enhanced nephrolithiasis and induced aortal mediacalcinosis in hypokinetic rats. These data indicate that phosphorus consumption should be reduced in order to prevent disorders in phosphorus-calcium metabolism during hypokinesia. They also suggest that administration of 1 alpha OHD3 may be hazardous in case of excessive phosphorus consumption.
N V Blazheevich, and
V B Spirichev, and
A S Ushakov, and
M S Belakovskiĭ, and
A L Pozdniakova
September 1978,
The British journal of nutrition,
N V Blazheevich, and
V B Spirichev, and
A S Ushakov, and
M S Belakovskiĭ, and
A L Pozdniakova
September 1980,
The British journal of nutrition,
N V Blazheevich, and
V B Spirichev, and
A S Ushakov, and
M S Belakovskiĭ, and
A L Pozdniakova
November 1994,
The Journal of dairy research,
N V Blazheevich, and
V B Spirichev, and
A S Ushakov, and
M S Belakovskiĭ, and
A L Pozdniakova
January 1979,
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N V Blazheevich, and
V B Spirichev, and
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A L Pozdniakova
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Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
N V Blazheevich, and
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A L Pozdniakova
July 1978,
The British journal of nutrition,
N V Blazheevich, and
V B Spirichev, and
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M S Belakovskiĭ, and
A L Pozdniakova
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N V Blazheevich, and
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N V Blazheevich, and
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A L Pozdniakova
February 1979,
Polskie Archiwum Medycyny Wewnetrznej,
N V Blazheevich, and
V B Spirichev, and
A S Ushakov, and
M S Belakovskiĭ, and
A L Pozdniakova
August 1981,
Archives of biochemistry and biophysics,
