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Plasma prolactin (PRL) levels modifications after acute administration of L-dopa, L-dopa plus carbidopa and L-dopa plus benserazide were studied in parkinsonian patients. PRL increase after benserazide was compared with PRL response after carbidopa at the same dosage in untreated parkinsonian patients. A further study of the hyperprolactinemic effect of benserazide was performed in vitro on isolated and dispersed rat pituitary cells. The data gathered indicate that benserazide-induced hyperprolactinemia in parkinsonian patients could be due to a direct effect of the drug at the hypothalamic level and consequently to an inhibition of dopamine decarboxylation in the tuberoinfundibular dopaminergic system. It is not possible to exclude, however, that benserazide could exert its biological activity through the production of active metabolites in vivo.
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P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
January 1972,
Zeitschrift fur Neurologie,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
February 2014,
Parkinsonism & related disorders,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
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S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
February 1974,
Ugeskrift for laeger,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
March 1974,
La Revue du praticien,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
January 1975,
Acta neurologica Belgica,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
September 1970,
Lancet (London, England),
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
June 1973,
Nature,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
January 1971,
La Presse medicale,
S Ruggieri, and
P Falaschi, and
M Baldassarre, and
R D'Urso, and
G De Giorgio, and
A Rocco, and
A Agnoli
January 1972,
Zeitschrift fur Neurologie,
