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Comparisons of isonitrogenous supplements (1.2 g N) of essential amino acids and five keto acid analogues with four essential amino acids were made in seven patients with stable chronic renal failure (creatinine clearance, 4.6 to 16 ml/min) on moderately protein-restricted diets (4.60 to 7.8 g N per day). Full nitrogen balance data on the four patients who have already completed studies lasting 24 weeks are presented. No benefits of keto acid over amino acid supplements were observed. Two transient episodes of hypercalcemia occurred during keto acid treatment. There was no improvement of renal function with keto acids. Also, no carry-over effects were seen after keto acid treatment. It is concluded that any beneficial effects of keto acids in patients with chronic renal failure are only likely to occur in those taking a diet of less than 30 g protein daily.
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
January 1986,
Contributions to nephrology,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
January 1986,
Contributions to nephrology,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
December 1983,
Kidney international. Supplement,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
October 1978,
The American journal of clinical nutrition,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
January 1980,
Acta chirurgica Scandinavica. Supplementum,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
July 1980,
The American journal of clinical nutrition,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
September 2009,
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
August 1976,
Gastroenterology,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
January 1986,
Contributions to nephrology,
J Burns, and
E Cresswell, and
S Ell, and
M Fynn, and
M A Jackson, and
H A Lee, and
P Richards, and
A Rowlands, and
S Talbot
June 1978,
Clinical science and molecular medicine,
