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Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis. This is a significantly greater anti-inflammatory effect than we have previously reported for the alcohol derivative of fluorometholone and is not significantly different from the therapeutic effect of 1.0% prednisolone acetate ophthalmic suspension, the most effective corneal anti-inflammatory agent that we have studied to date. Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension.
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A R Berrospi, and
H M Leibowitz
January 2000,
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A Kupferman, and
A R Berrospi, and
H M Leibowitz
March 1997,
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A Kupferman, and
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H M Leibowitz
July 2007,
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A Kupferman, and
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A Kupferman, and
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A Kupferman, and
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A Kupferman, and
A R Berrospi, and
H M Leibowitz
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