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The purpose of this investigation was to determine the frequency and severity of small intestinal mucosal damage in pseudoobstruction syndromes. One hundred eighty-nine interpretable biopsies from 12 patients were blindly reviewed by two investigators. The underlying disorders were scleroderma in 7 and idiopathic intestinal pseudoobstruction in 5. All 12 had small-intestinal dilatation on small-bowel series. Eight of the 12 patients had biopsies characterized by moderate to severe mucosal damage; 3 of these had some biopsies which were flat. The damage did not correlate with: (1) types and numbers of organisms recovered from small intestinal aspirates; (2) duration of illness; (3) degree of dilatation of the proximal small bowel; (4) concentrations of deconjugated bile salts in small intestinal fluid; or (5) amount of fat absorbed in fat-balance studies. We conclude that mucosal damage is common in pseudoobstruction syndromes. The pathogenesis of the damage and its relationship to intraluminal bacteria remain undefined.
M D Schuffler, and
L R Kaplan, and
L Johnson
July 1981,
American journal of human genetics,
M D Schuffler, and
L R Kaplan, and
L Johnson
June 1978,
Gastroenterology,
M D Schuffler, and
L R Kaplan, and
L Johnson
January 2008,
Acta chirurgica Iugoslavica,
M D Schuffler, and
L R Kaplan, and
L Johnson
December 1984,
Journal of pediatric surgery,
M D Schuffler, and
L R Kaplan, and
L Johnson
October 1987,
Gastroenterology,
M D Schuffler, and
L R Kaplan, and
L Johnson
August 2004,
Current treatment options in gastroenterology,
M D Schuffler, and
L R Kaplan, and
L Johnson
May 1978,
Gastroenterology,
M D Schuffler, and
L R Kaplan, and
L Johnson
November 2011,
Gastroenterologia y hepatologia,
M D Schuffler, and
L R Kaplan, and
L Johnson
January 1990,
Lijecnicki vjesnik,
M D Schuffler, and
L R Kaplan, and
L Johnson
January 1992,
Journal of clinical gastroenterology,
