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Investigation of monoclonal gammapathies by immunoelectrophoresis and immunofixation. 1982

M R Pudek

UI MeSH Term Description Entries
D007122 Immunoelectrophoresis A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
D007136 Immunoglobulins Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses. Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D001796 Blood Protein Disorders Hematologic diseases caused by structural or functional defects of BLOOD PROTEINS. Blood Protein Disorder,Disorder, Blood Protein,Disorders, Blood Protein,Protein Disorder, Blood,Protein Disorders, Blood
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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[Immunoelectrophoresis or immunofixation: identification of monoclonal gammopathy].
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Immunofixation cannot replace immunoelectrophoresis.
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Immunofixation can replace immunoelectrophoresis.
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More on immunofixation vs immunoelectrophoresis.
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Comparison of immunofixation and immunoelectrophoresis methods in the identification of monoclonal immunoglobulins in serum.
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[Benign monoclonal gammapathies].
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Detection and identification of monoclonal components: immunoelectrophoresis on agarose gel and immunofixation on cellulose acetate compared.
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