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A new method for the selective synthesis of unsymmetrical cystine peptides. 1982

E Wünsch, and S Romani

A convenient method for the synthesis of unsymmetrical cystine peptides is described, which is based on the conversion of one cysteine component to the corresponding sulfenohydrazide by reaction with azodicarboxylic acid derivatives. Following the isolation and characterization of this S-activated intermediate, its thiolysis via the second cysteine component leads to the desired disulfide bridging.

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D009842 Oligopeptides Peptides composed of between two and twelve amino acids. Oligopeptide
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D003553 Cystine A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine. Copper Cystinate,L-Cystine,L Cystine
D004220 Disulfides Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties. Disulfide
D005563 Formic Acid Esters ESTER derivatives of formic acid with the formula H-COO-R. Formate Esters,Acid Esters, Formic,Esters, Formate,Esters, Formic Acid

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