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One hundred one volunteers with no exposure to rabies were given human diploid cell vaccine (HDCV) for rabies with or without 20 international units of human rabies immune globulin (HRIG)/kg of body weight to evaluate schedules for therapy with HDCV and HRIG after exposure. All of the volunteers who received three or more doses of HDCV alone or four or more doses of HDCV with HRIG developed high titers of neutralizing antibodies by day 35, which persisted for at least 60 days. By day 7, of the 61 volunteers given HRIG and HDCV, 53% had neutralizing antibodies by a mouse neutralization test and 67% had neutralizing antibodies by a rapid fluorescent focus inhibition test. Similar antibody levels were found in volunteers given HRIG alone, a finding which suggests that low or undetectable early titers after administration of HDCV and HRIG were due to inadequate HRIG dosage rather than any interaction between the passive antibody (HRIG) and the vaccine antigen. These results suggest that trials with 30 or 40 international units of HRIG/kg in combination with HDCV are warranted.
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
November 1987,
MMWR. Morbidity and mortality weekly report,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
September 1979,
American journal of epidemiology,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
October 1991,
The American journal of medicine,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
July 1978,
Journal of biological standardization,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
January 1988,
JAMA,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
March 1974,
Applied microbiology,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
May 1984,
Lancet (London, England),
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
November 1982,
JAMA,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
January 1978,
Developments in biological standardization,
G J Mertz, and
K E Nelson, and
V Vithayasai, and
S Makornkawkeyoon, and
E I Rosanoff, and
H Tint, and
T J Wiktor
March 1981,
American journal of epidemiology,
