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The effects of a single large intravenous dose of methylprednisolone on the steady state levels of dopamine, norepinephrine, and 5-hydroxytryptamine in cat lumbar spinal cord, as a function of dose (15, 30, or 90 mg/kg) and time (1 or 24 h) after administration, were examined by high performance liquid chromatography with electrochemical detection. Methylprednisolone produced a dose-related increase in the levels of dopamine and 5-hydroxytryptamine, but not norepinephrine, measured at 1 h. The effect of the single glucocorticoid dose was biphasic, however, as measurement of the three amines at 24 h showed each to be depressed below the levels found in untreated animals. The possible mechanistic basic and the significance of these glucocorticoid effects are discussed.
E D Hall, and
P A McGinley
January 1968,
Proceedings of the Western Pharmacology Society,
E D Hall, and
P A McGinley
January 1973,
Psychopharmacologia,
E D Hall, and
P A McGinley
January 1983,
Beitrage zur gerichtlichen Medizin,
E D Hall, and
P A McGinley
January 1975,
Pharmacology, biochemistry, and behavior,
E D Hall, and
P A McGinley
January 1975,
Neuroendocrinology,
E D Hall, and
P A McGinley
January 1982,
Drug metabolism and disposition: the biological fate of chemicals,
E D Hall, and
P A McGinley
April 1980,
Nihon Seikeigeka Gakkai zasshi,
E D Hall, and
P A McGinley
August 1983,
Journal of neurosurgery,
E D Hall, and
P A McGinley
April 1972,
The Journal of pharmacology and experimental therapeutics,
E D Hall, and
P A McGinley
April 1987,
Brain research,
