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Efficacy of minipress in patients with hypertension stage II and its haemodynamic effects were studied after a single administration and during a course of treatment. It is shown that its main mechanism is in vasodilatation caused by relaxation of the muscular component of arterioles. The authors suggest that minipress can produce redistribution of the blood through peripheral venoconstriction. Decrease of the index of the external work of the heart points indirectly to decreased oxygen utilization by the myocardium which may reflect changes in haemodynamics under the influence of minipress or through direct action of the drug on the heart. Hypotensive effect of minipress is recorded already by the 5th day of its administration (p less than 0.001), however, its further effect is unstable. Increase of the circadian dose becomes necessary and also its combined use with thiazide diuretics. Positive chronotropic effect of Minipress has been recorded, with maximum towards the end of the 2nd week of treatment and seen as increased rate of cardiac contractions by 13.2% (p less than 0.01). To decrease this effect authors advise to use minipress in combination with beta-adrenoblockers.
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
July 1977,
JAMA,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
January 1977,
Bollettino della Societa italiana di cardiologia,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
January 1977,
Kardiologia polska,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
July 1979,
Der Urologe. Ausg. A,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
April 1980,
The Journal of the Maine Medical Association,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
January 1977,
The Medical letter on drugs and therapeutics,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
August 1971,
British journal of pharmacology,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
July 1977,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
April 1976,
The Medical journal of Australia,
V G Kukes, and
S B Zisel'man, and
G B Shustikova, and
A S Rumiantsev, and
E V Shagako
August 1989,
The American journal of medicine,
