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Three carcinogens with different requirements for activation were used to generate sister chromatid exchange (SCE) in cultured lymphocytes from 22 untreated patients with solid tumors. These data were compared to SCEs produced by incubating lymphocytes, from 44 normal persons, with the same carcinogens. In vitro treatments with butadiene epoxide (0.125 micrograms/ml) show no significant differences in the SCEs generated. However, in vitro treatment with mitomycin-C (0.04 micrograms/ml) did induce significant differences (p less than 0.05) in the distribution of the SCE scores. Treatment of the cultured cells with benzo(a)pyrene (10 micrograms/ml), a carcinogen requiring extensive metabolic activation, significantly (p less than 0.001) altered the distribution of the SCEs generated in vitro. The SCE data suggest that metabolic activities play an important role in the processing of carcinogens in solid tumor patients.
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
October 1978,
Human genetics,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
January 1984,
Indian journal of pediatrics,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
November 1983,
Mutation research,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
July 1985,
Mutation research,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
November 1979,
Human genetics,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
January 1980,
Environmental mutagenesis,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
May 1981,
Mutation research,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
September 1989,
Mutation research,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
October 1981,
Journal of the National Cancer Institute,
J K Wiencke, and
J Vosika, and
P Johnson, and
N Wang, and
V F Garry
May 1979,
Journal of the National Cancer Institute,
