Biomaterial Database

[Pharmacological properties of water-soluble levorin]. 1978

N A Peshkova

The results of the study of the pharmacological properties of the preparation of 5 per cent levorin solution in 40 per cent sodium salicylate solution are presented. The toxicity of levorin contained in the preparation was studied in the acute experiment on its intraperitoneal administration to mice. It did not differ from that of sodium levorin. In concentration of 5000 units/ml with respect to levorin the preparation did not change the motion speed of the ciliated epithelium cilia of the frog esophagus when used in the form of aerosol. Innocuousness of the preparation used repeatedly for inhalation in the form of aerosol was studied. The preparation was innocuous in the doses 12 and 24 times higher than the therapeutic ones. When applied locally on the skin and the eye conjunctiva for 16-20 days the preparation in the respective pharmaceutical forms was innocuous. Absorption and distribution of the water-soluble levorin in mice treated with the drug intraperitoneally or inhalationally was studied. It was found that levorin contained in the preparation circulated in the blood in bacteriostatic concentrations after its intraperitoneal administration for 8 hours. When used as inhalation in the form of aerosol levorin was detected in the lungs and urine and circulated in concentrations exceeding the bacteriostatic ones for 12 hours.

UI	MeSH Term	Description	Entries
D007928	Lethal Dose 50	The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.	LD50,Dose 50, Lethal
D001769	Blood	The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
D002174	Candicidin	Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.	Levorin,Candeptin,Candicidin D,Candimon,Levorine,Vanobid
D002923	Cilia	Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)	Motile Cilia,Motile Cilium,Nodal Cilia,Nodal Cilium,Primary Cilia,Primary Cilium,Cilium,Cilia, Motile,Cilia, Nodal,Cilia, Primary,Cilium, Motile,Cilium, Nodal,Cilium, Primary
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000935	Antifungal Agents	Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.	Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics