The main toxic component isolated from several varieties of kidney bean (Phaseolus vulgaris) is a haemagglutinating lectin. The inclusion in rat diets of raw kidney beans or purified bean lectins results in abnormal development of microvilli in the small intestine. Immunocytochemical investigations have provided evidence that this lesion is associated with the binding of lectins to the luminal surfaces of enterocytes. The lectin-induced disruption of intestinal microvilli may result in interference with the intermediate and final stages of nutrient hydrolysis in the gut. In nitrogen balance studies it was found that rats ingesting pure bean lectins were in negative nitrogen balance. These nitrogen losses may have been partly the result of systemic effects, possibly caused by a selective uptake of lectins by the gut.