Biomaterial Database

Measurement of the rate of secretion, peripheral metabolism and interconversion of cortisol and cortisone in adult conscious male guinea-pigs. 1982

M Manin, and C Tournaire, and P Delost

Metabolism of the cortisol (F) and the cortisone (E) was studied by continuous infusion of [14C]-F and [3H]-E in adult conscious male guinea-pigs. Parameters, calculated from the specific activities of F and E, are expressed in mumoles/24 h : production rate of F (PRF) = 8 +/- 1 and E (PRE) = 4.9 +/- 0.7 ; secretion rate of F (QF) = 7.1 +/- 0.9 and E (QE) = 0.9 +/- 0.4 ; rate of irreversible metabolism of F (rF) = 6.2 +/- 0.9 and E (rE) = 1.8 +/- 0.3 ; percentage of transfer of F into E = 59 +/- 4% and E into F = 80 +/- 3%. These results demonstrate that adrenal gland in the adult male guinea-pig secretes essentially cortisol and little or no cortisone. Practically all the pool of E is derived from transformation of F into E ; the major part of E production is reconverted into F.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008657	Metabolic Clearance Rate	Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.	Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D003348	Cortisone	A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)	17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate,Adreson,Cortisone Acetate,Cortone Acetate
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006854	Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.	Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia