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In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment).
K Hiller, and
P Meyer, and
K Wilms
August 1986,
Cancer research,
K Hiller, and
P Meyer, and
K Wilms
November 1967,
Journal of the National Cancer Institute,
K Hiller, and
P Meyer, and
K Wilms
January 1978,
Voprosy onkologii,
K Hiller, and
P Meyer, and
K Wilms
February 1968,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K Hiller, and
P Meyer, and
K Wilms
December 1972,
Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research,
K Hiller, and
P Meyer, and
K Wilms
September 1959,
Nature,
K Hiller, and
P Meyer, and
K Wilms
January 1973,
Experimental hematology,
K Hiller, and
P Meyer, and
K Wilms
October 1970,
Journal of the National Cancer Institute,
K Hiller, and
P Meyer, and
K Wilms
March 1980,
Transplantation proceedings,
K Hiller, and
P Meyer, and
K Wilms
May 2004,
Cancer science,
