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A new pyrimidine nucleoside, 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil, previously has been shown to be active against the herpes group of viruses in vitro and in vivo. It is also active against mouse and human leukemic cells in culture and against mouse leukemias L1210, P388, and P815 in vivo. In contrast to other 1-beta-D-arabinofuranosylcytosine (ara-C) derivatives, 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil, when given either i.p. or p.o., is highly active against lines of leukemias P815 and L1210 made resistant to ara-C. Against P815/ara-C and L1210/araC, it is more effective than is 5-azacytidine, a drug which has shown definite effectiveness in patients with acute leukemia whose disease has become resistant to ara-C. For these reasons, 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil would seem to merit clinical trial in patients with acute nonlymphocytic leukemia whose disease has become resistant to ara-C.
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
February 1983,
Biochemical pharmacology,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
June 1991,
The Journal of infectious diseases,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
July 1989,
Japanese journal of cancer research : Gann,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
January 1991,
Leukemia research,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
January 1984,
Leukemia research,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
September 1981,
Cancer research,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
October 1983,
Cancer research,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
November 1985,
Cancer research,
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
December 1962,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J H Burchenal, and
T C Chou, and
L Lokys, and
R S Smith, and
K A Watanabe, and
T L Su, and
J J Fox
January 1990,
Journal of medicinal chemistry,
