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By means of a double-labelling experiment, circadian variations in the kinetic parameters of the S phase of the hamster cheek pouch epithelium were studied. The evaluation of the experiment included a recently developed correction for deviations from the strict pulse interpretation of the labelling technique. Pronounced circadian variations were found in S phase influx and efflux; the diurnal mean of both was estimated as 0.5%/hr, when based on measurements of all nucleated epithelial cells. Variations in S phase influx seem mainly responsible for the diurnal variation in cell proliferation, although diurnal variation in DNA synthesis rate, and thus in mean transit time, was also found. The increases in LI and influx were closely correlated and related to the beginning of the dark period. A circadian variation in cell number was also observed.
U Møller, and
N Keiding
February 1996,
Cell proliferation,
U Møller, and
N Keiding
December 1969,
Radiation research,
U Møller, and
N Keiding
May 1974,
Cell and tissue kinetics,
U Møller, and
N Keiding
January 1972,
Experimental cell research,
U Møller, and
N Keiding
January 1990,
Virchows Archiv. B, Cell pathology including molecular pathology,
U Møller, and
N Keiding
November 1979,
Cell and tissue kinetics,
U Møller, and
N Keiding
July 1987,
Cell and tissue kinetics,
U Møller, and
N Keiding
January 1981,
Archives of oral biology,
U Møller, and
N Keiding
July 1977,
Cell and tissue kinetics,
U Møller, and
N Keiding
January 1979,
Progress in experimental tumor research,
