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The metabolism of [2-14C]folic acid over 13 days and a mixture of [2-14C]- and [3',5',9-3h]-folic acid in rats over a 6-day period is described. Both 14C and 3H are excreted in urine over the 6-day period, but 3H and 14C are only detectable in faeces for 2 days. A breakdown product of folic acid labelled with 3H only was found in some urine samples, but no metabolite corresponding to the part of the molecule containing 14C was detected. These experiments show that in the whole animal a substantial portion of orally administered folic acid undergoes scission shortly after administration [Blair Biochem. J. (1957) 68, 385-387] and that the retained folates are a shortage form for folate monoglutamates.
P A Barford, and
F J Staff, and
J A Blair
March 1979,
Toxicology and applied pharmacology,
P A Barford, and
F J Staff, and
J A Blair
January 1976,
Journal of agricultural and food chemistry,
P A Barford, and
F J Staff, and
J A Blair
February 1983,
The Japanese journal of experimental medicine,
P A Barford, and
F J Staff, and
J A Blair
April 1977,
Xenobiotica; the fate of foreign compounds in biological systems,
P A Barford, and
F J Staff, and
J A Blair
June 1973,
Xenobiotica; the fate of foreign compounds in biological systems,
P A Barford, and
F J Staff, and
J A Blair
December 1968,
Archives internationales de physiologie et de biochimie,
P A Barford, and
F J Staff, and
J A Blair
January 1994,
Drug metabolism and disposition: the biological fate of chemicals,
P A Barford, and
F J Staff, and
J A Blair
March 1983,
Lipids,
P A Barford, and
F J Staff, and
J A Blair
March 1986,
Arzneimittel-Forschung,
P A Barford, and
F J Staff, and
J A Blair
January 1980,
The International journal of biochemistry,
