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The effect of systemic 8-methoxypsoralen (8-MOP; 100 mg/kg daily) and subsequent long ultraviolet irradiation (UVA; 300 mJ/cm2; peak: 365 nm) on albino and pigmented rat eyes was studied in a 3-dimensional experimental set-up. While 8-MOP and UVA did not cause any ocular pathology when administered alone, a combined application of the two factors caused reversible corneal opacities, and irreversible iris devascularisation and cataracts. The irreversible changes were seen only in the albinos and accompanied by a significant decrease in lens wet weight. Phosphorescence and EPR spectroscopy demonstrated the formation of an 8-MOP-protein photoadduct in the animals treated with both 8-MOP and UVA. The results of this study emphasize the necessity of shielding the eyes of patients on photochemotherapy with protective spectacles.
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
September 1977,
Nippon Ganka Gakkai zasshi,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
September 1976,
Ugeskrift for laeger,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
February 1995,
Biochemical and biophysical research communications,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
October 1981,
The Journal of investigative dermatology,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
July 1976,
Nederlands tijdschrift voor geneeskunde,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
October 1982,
International journal of dermatology,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
January 1989,
The Journal of investigative dermatology,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
August 1981,
Nippon Ganka Gakkai zasshi,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
March 1961,
The Journal of pharmacology and experimental therapeutics,
H R Koch, and
R Beitzen, and
F Kremer, and
G Chioralia, and
H Baurmann, and
J Megaw, and
K Gardner, and
S Lerman
April 1958,
Science (New York, N.Y.),
